Hydrocortisone + Fusidic acid

Topical/Cutaneous
Mild atopic dermatitis with secondary bacterial infection, Moderate atopic dermatitis with secondary bacterial infection

Hypersensitivity to fusidic acid and its salts. Bacterial infections caused by non-susceptible organisms, fungal infections, skin manifestations due to tuberculosis, syphilis, perioral dermatitis and rosacea.

Not to be used in or near the eye(s) as it may cause conjunctival irritation; may also increase the risk of increased intraocular pressure, glaucoma and cataract. Sufficient dermal absorption may occur under occlusive dressing leading to adrenal suppression and other systemic effects. May mask hypersensitivity reactions. Not to be used for >14 days in the absence of any clinical improvement. Pregnancy and lactation.

Dryness, itching, burning, local irritation, transient stinging, striae, skin atrophy. Pigmentation changes, hypertrichosis and telangiectasia may occur. Acne rosacea or perioral dermatitis may occur if used on the face.

Description:
Mechanism of Action: Hydrocortisone is a corticosteroid that has anti-inflammatory, antipruritic and vasoconstrictive effects. Fusidic acid has antibacterial action that results from the inhibition of bacterial protein synthesis; it is mainly active towards the gram-positive organisms especially Staph aureus.
Pharmacokinetics:
Absorption: Hydrocortisone: Dermal absorption accounts for about 1-5% of the applied amount. Fusidic acid: About 2% of the amount that is applied topically will penetrate intact skin.

Store at 15-30°C.

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